Psychogenic factors can be powerful contributors of CPP, as predisposing, precipitating or maintaining factors of chronic stress. One of the currently most credited pathophysiologic reading is through the corticotropin-releasing factor (CRF) signaling pathways.
The paper updates the word ”psychogenic”; suggests a pathophysiologic reading of the psychogenic contribute to CPP, via the stress-induced corticotropin-releasing factor (CRF) signaling pathways, and differentiates predisposing, precipitating and maintaining factors; summarizes the pertinent evidence; focuses on the differential diagnosis between prominent “psychogenic” vs somatic etiology of CPP; highlights the common diagnostic mistakes with a focus on iatrogenic factors and nocebo effect; discusses the psychological and sexual consequences of CPP.
The paper updates the word ”psychogenic”; suggests a pathophysiologic reading of the psychogenic contribute to CPP, via the stress-induced corticotropin-releasing factor (CRF) signaling pathways, and differentiates predisposing, precipitating and maintaining factors; summarizes the pertinent evidence; focuses on the differential diagnosis between prominent “psychogenic” vs somatic etiology of CPP; highlights the common diagnostic mistakes with a focus on iatrogenic factors and nocebo effect; discusses the psychological and sexual consequences of CPP.