Testosterone substitution in women

Neurobiology of sexual desire and central (mental) arousal, and the peripheral neurovascular response are substantially modulated by sexual hormones. Androgens have a leading role in the initiation and modulation of sexual function, in women as in men. Much of the current understanding of androgen effects in women has been derived from the symptomatology of women with androgen insufficiency. The pattern of symptoms, and symptom frequency, following bilateral oophorectomy (surgical menopause) has validated their tie to androgen deficiency.