Depression and menopause: why antidepressant are not enough

Women are more prone than men to depression, from puberty onwards, with a specific exposure across the menopausal transition, that contributes to a specific “window of vulnerability”.
The current evidence contributes to a re-reading of the relationship between menopause and depression. The combination of antidepressants with a well tailored hormone therapy seems to offer the best therapeutic potential in terms of efficacy, rapidity of improvement and consistency of remission in the follow-up.